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Our team explores the dynamic of pathophysiological processes that underlie the initiation and progression of cardiac pathologies from childhood to adult. Based on a strong cooperation between basic science researchers and clinicians, we investigate the mutual interaction of ionic homeostasis and cellular excitability from molecular to integrative aspects in the contexts of Cardio-metabolic, Neuro-cardiac and Cardio-inflammatory couplings.
Only an adapted metabolism, a fine autonomous control of the heart rate and a controlled level of inflammation, together allow an effective excitability dedicated to the initiation of the cardiac contraction. Briefly, our team aims to decipher the role of mitochondria and related functions to maintain both energy supply and intracellular ionic homeostasis, and conversely, in several cardiac diseases including channelopathies or during metabolism defects. We will focus on the central role of autonomic nervous system in the development of cardiac pathologies, in particular, on arrhythmia genesis on acquired, inherited and congenital situations. We also investigate the myocardial dysfunction in chronic inflammatory disorders to provide a comprehensive picture of the underlying mechanisms leading to severe cardiovascular events.
Theses 3 main axes will be addressed by specific translational objectives where a broad variety of up-to-date methodological approaches combining genetic to molecular biology, molecular to in vivo electrophysiology and imaging will be used both in human (hiPSC-derived cardiomyocytes) and animal models. Together, we will bring novel concept to better prevent and treat electrical dysfunction and to improve current therapeutic strategy in these life-threatening diseases.